Tuesday, August 17, 2010

Creatinine

Creatinine

Introduction

Serum Creatinine is the most specific and sensitive indicator of renal disease. Use of BUN and Creatinine levels together is more informative in renal disorders.

      

Normal Range

    Male

        Female

         Fetal

  Pregnancy

 0.7 - 1.4 mg/dL

  0.6 – 1.1 mg/dL

   0.4 – 0.9 mg/dL

0.4 – 0.6 mg/dL

 

Indications

       Diagnosis of renal insufficiency

 

Increased in

Diet [ingestion of Creatinine (roast meat); prerenal azotemia; postrenal azotemia; impaired kidney function, 50% of renal function is needed to increase serum Creatinine from 1.0 – 2.0mg/dl. Therefore, not sensitive to mild – to moderate renal injury.

Decreased in

Pregnancy – normal value is 0.4 – 0.6 mg/dL. > 0.8mg/Dl is abnormal and should alert clinician to further diagnostic evaluation.

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