Mean Corpuscular Volume (MCV)
Introduction
MCV is calculated as hematocrit (Hct) divided by RBC count with manual methods measured directly by automated instruments.
Normal range
Adults – 78-100Fl
Neonates- 102-115Fl.
Indications
Classification and differential diagnosis of anemia; useful screening test for occult alcoholism
Increased in (MCV > 95fL, Often > 110Fl)
All macrocytic anemias (megaloblastic anemias, Vit. B12’ folate deficiency, sprue, macrocytic anemia of pregnancy, megaloblastic anemia due to alcoholism, liver disease and hypothyroidism), infants and newborns.
Decrease in (MCV < 80FL)
Microcytic anemias
Usually hypo chromic (e.g. iron deficiency, pyridoxine – responsive thalassemia, lead poisoning), chronic disease, abnormal HbC and HbE.
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