Monday, August 16, 2010

High Density Lipoprotein (HDL) Cholesterol (Lipid Profile)

1.      High Density Lipoprotein (HDL) Cholesterol

Introduction

Levels of HDL are inversely related to risk of CAD. For every mg/dL decreased in HDL, risk of CAD increase by 2 -3%

 

Indications

Assessment of risk of CAD

 

Diagnosis of various lipoproteinemia

 

Normal Levels

          Men

         Women

   > 40mg/dL

  > 50mg/dL

 

Increased in (60mg/Dl is negative risk factor for CAD)

 

Vigorous exercise; moderate consumption of alcohol; Increased clearance of triglyceride (VLDL), Familial lipid disorders with protection against atherosclerosis (illustrates importance of measuring HDL to evaluate hypercholesterolemia); 1 in 20 adults with mild increased total cholesterol levels (240 – 300mg/dL) secondary to increased HDL ( > 70mg/dL); Hypobetalipoproteinemia.

 

Decreased in (< 32mg/dL in men, < 38mg/dL in women)

Stress and recent illness (e.g. acute myocardial infarction [AMI], stroke, surgery, trauma); starvation, non fasting sample; obesity and lack of exercise; cigarette smoking; DM, hypo – and hyper – thyroidism; acute and chronic liver disease; genetic disorders; familial hypoalphalipoproteinemia.

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