Wednesday, August 11, 2010

Causes of monocytosis ( > 10% of differential absolute count > 500/cu.mm.)

Causes of monocytosis ( > 10% of differential absolute count  > 500/cu.mm.)

Monocytic leukemia, other myeloproliferative disorders, lymphomas, lipid storage diseases, post splenectomy, protozoal and some rickettsial infections, SBE, tuberculosis, brucellosis sarcoidosis, rheumatoid arthritis, systemic lupus erythematosus(SLE).

Causes of basopenia

Causes of basopenia

Hyperthyroidism, pregnancy, irradiation, chemotherapy, glucocorticoid administration, acute phase of infection.

Basophilia (50/cumm or > 1%)

Basophilia (50/cumm or > 1%)

May be first sign of blast crisis or accelerated phase of chronic myelocytic leukemia (CML).

Persistent basophilia may indicate unsuspected myeloproliferative disease.

Causes

Chronic myelogenous leukemia, basophilic leukemia, polycythemia, myeloid metaplasia, Hodgkin's disease, chronic sinusitis and hemolytic anemia.