Causes of lymphocytopenia (Decreased Lymphocytes) (< 1500 in adults, < 3000 in children)

Causes of lymphocytopenia (< 1500 in adults, < 3000 in children)

Increased destruction (chemotherapy or radiation treatment, corticosteroids), 

increased loss via Gl tract (thoracic duct drainage obstruction to intestinal lymphatic duct drainage), 

congestive heart failure, 

decreased production (aplastic anemia, malignancy, AlDS).

Causes of lymphocytosis (Increased Lymphocytes) (> 4000/cumm in adults, > 7200/cumm adolescents, > 9000/cumm in children and infants)

Causes of lymphocytosis (> 4000/cumm in adults, > 7200/cumm adolescents, > 9000/cumm in children and infants)

Infection (Pertusis, infectious, lymphocytosis, infectious hepatitis, cytomegalovirus (CMV) infections, mumps, rubella, varicella, toxoplasmosis, chronic tuberculosis), 

Others like 

thyrotoxicosis,

Addison's disease, 

neutropenia with relative lymphocytosis, 

lymphatic leukemia, 

Crohn's disease, 

ulcerative colitis and 

infancy (normal count 40- 60 %) called relative lymphocytosis.

Causes of Neutropenia (Decreased Neutrophil) (Absolute count < 8000/ cu.mm.)

Causes of Neutropenia (Absolute count < 8000/ cu.mm.)

·        Infections: bacterial (e.g. overwhelming infection, septicemia, typhoid, paratyphoid) viral infections (infectious mononucleosis, hepatitis, influenza, measles, rubella), rickettsia, others (malaria, kala- azar).

·        Infants (normal count 40%).

·        Hodgkin's disease, chronic sinusitis, hemolytic anemia and lonizing radiation

·        Drugs & chemical (antibiotics, analgesics, antithyroids, arsenicals and ionizing radiation

·        Hematopoietic diseases (aleukemic leukemia, aplastic anemia) and splenic sequestration.

·        Autoimmune and isoimmune neotropenias.

·        Immune defects like infertile genetic agranulocytosis.